Microbial Isolate Among Women with Premature Rupture of Foetal Membranes and Pregnancy Outcome in National Hospital Abuja.

Abstract

ABSTRACT

Background: Premature rupture of foetal membranes is a significant contributor to perinatal morbidity and mortality, and in the tropics where there is lack of facilities for intensive neonatal care, this poses a significant therapeutic dilemma in current obstetrics practice.

Aim: To determine the profile of microorganisms, their antimicrobial sensitivity pattern, gestational age at delivery, mode of delivery, cases of neonatal sepsis and cases of endometritis.

Methodology: A prospective study was conducted among pregnant women presenting with premature rupture of foetal membranes at National Hospital Abuja. The Participant were recruited consecutively and a structured interviewer questionnaire was completed. Endocervical and high vaginal swab were collected to isolate microorganism and their sensitivity pattern was investigated, the subject were followed up till delivery and outcome of pregnancy was noted.    

Results: A total of 101 cases of PROM were analysed, pathogens were isolated in 20.9% of cases. The common organisms isolated are Candida albicans (8.9%), Staphylococcus aureus (5.0%) and Escherichia coli (3.0%). Most of the organisms were sensitive to Ceftriaxone, Amoxyclav and Imepemen.  Vaginal delivery was the mode of delivery in 56.4% and 51.5% had preterm delivery. Neonatal sepsis was seen in 3% of the new born and no cases of maternal endometritis were recorded.

Conclusion: It has been shown from this study that some pathogens are associated with PROM. The study also found that Ceftriaxone and Imepenem were the antibiotics with highest sensitivity. Therefore, Prophylactic use of antibiotic should be based on demonstrated microbial pattern and their sensitivity. There is also need to further explore the association of candida with PROM since it is the commonest organism isolated in the study.

 Keywords: Microbial isolate, sensitivity, PROM, microorganism.